Color Blindness Research Today is a free monthly online journal that collates and summarizes the latest research about Color Blindness, including details on causes, classification, red-green and blue-yellow color blindness, diagnosis.

Effect of age on the development of a latanoprost-induced increase in iris pigmentation.

Arranz-Marquez E, Teus MA

Vissum Hospital Oftalmológico Madrid, Madrid, Spain. e.arranzmarquez@gmail.com

PURPOSE: To study the effect of patient age on the incidence of latanoprost-induced increases in iris pigmentation. DESIGN: Prospective observational observer-masked study. PARTICIPANTS: Thirty-six patients younger than 60 years (group 1) and 36 patients older than 75 years (group 2) with primary open-angle glaucoma. METHODS: We photographed both irises of each patient before and 6 months after unilateral latanoprost therapy. The basal iris colors were matched in both groups. MAIN OUTCOME MEASURES: Iris heterochromia identification at the 6-month evaluation of the photographs. RESULTS: Twenty-eight patients (77.78%) in group 2 developed an increase in iris pigmentation compared with eight patients (22.22%) in group 1 (P = 0.0001, chi-square test). CONCLUSIONS: Age seems to be an important risk factor for latanoprost-induced iris color change.

Published 6 July 2007 in Ophthalmology, 114(7): 1255-8.
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